45-year-old patient admitted to the hospital after drug overdosing



Doctor's Information

Name : Morteza
Family : Sanei Taheri
Affiliation :Radiology Department,Shohada Tajrish Hospital,SBMU
Academic Degree : Associate Professor of Radiology
Email : This email address is being protected from spambots. You need JavaScript enabled to view it.
Resident : Afarin Sadeghian


Case Section



Patient's Information

Gender : Male
Age : 45


Clinical Summary

45-year-old patient admitted to the hospital after overdosing on benzodiazepine drugs


Imaging Findings

MR images demonstrate extensive supratentorial white matter signal changes as low SI on T1- and high SI on T2-weighted sequences matched with areas of restriction diffusion sequence and ADC map.CT scan images show diffuse hypodensity of the central white matter.Regarding to the patient history,all above findings are most compatible with anoxic leukoencephalopathy.


Differential Diagnosis



Final Diagnosis

Early white matter Changes in the setting of anoxic leukoencephalopathy


Discussion (Related Text)

White matter lesions typically become visible in the late subacute or chronic phase of evolution of anoxic-ischemic brain damage and worsen over time. It has been suggested that this delayed leukoencephalopathy may be more common after prolonged hypoxemia combined with hypotension and acidosis,yet surprisingly little research addressing this form of leukoencephalopathy has been reported in the literature. Early white matter changes have been observed in some patients.The actual prevalence of this fi nding is unclear, but from our experience, it is probably quite low.



Alejandro A. Rabinstein and Steven J. Resnick,F:Hypoxic-Ischemic Brain Damage, PROPERTY OF ELSEVIERF


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