A 45 years old female with headache



Doctor's Information

Name : Morteza
Family : Sanei Taheri
Affiliation :Radiology Department,Shohada Tajrish Hospital,SBMU
Academic Degree : Associate Professor of Radiology
Email : This email address is being protected from spambots. You need JavaScript enabled to view it.
Resident : mohadese mahvari


Case Section



Patient's Information

Gender : Female
Age : 45


Clinical Summary

45 years old female known case of breast cancer with complaint of headache


Imaging Findings

In T1 post gad images multiple enhancing lesion in posterior fossa is seen.also in post Gad images diffuse leptomeningeal enhancement due to meningeal carcinomatosis exists. This findings are secondary to breast cancer .


Differential Diagnosis



Final Diagnosis

Leptomeningeal carcinomatosis


Discussion (Related Text)

Leptomeningeal carcinomatosis (LC) refers to diffuse seeding of the leptomeninges by tumor metastases LC occurs in an estimated 20% of patients diagnosed with cancer and is most commonly found in breast carcinoma, lung carcinoma, and melanoma in adults and hematogenous malignancies and primitive neuroectodermal tumor (PNET) in children. Less commonly, prostate cancer can spread to the leptomeninges; this is a grim finding in this often treatable neoplasm. Antemortem diagnosis of LC is becoming more common, as newer therapies increase the life span of cancer patients and improvements in technology increase the sensitivity of imaging studies



Kleinfeld K, Peters WH, Stephenson C, Azar NJ. Leptomeningeal metastasis from occult signet-ring cell colon adenocarcinoma presenting with isolated headache. J Clin Neurosci. Jun 2013;20(6):890-2


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